Linkage analysis of congenital nuclear cataract and DLAD locus / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 625-627, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-641787
ABSTRACT
· AIM:
DLAD (DnaseII-like acid Dnase) is an acid DNase that is highly expressed in human and murine lens fibre cells. Recently, the DLAD-/- mice with a deficience in DLAD gene were reported to develop nuclear cataract.To elucidate whether a deficient DLAD gene can cause some human cataract, we studied autosomal dominant nuclear catarat in 6 families and analysed linkage between cataract and DLAD locus.·METHODS:
Two-point Lod score values were obtained for markers D1S551 and GATA65B07.·RESULTS:
The results show negative Lod scores (z=-∞ at θ =0), so linkage was excluded between the defect and DLAD locus in these families.·CONCLUSION:
no evidence for cataracts in these families linkage to chromosome 1p22.3, the DLAD locus.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
International Eye Science
Ano de publicação:
2005
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS