Expressions and clinical significance of PDCD4 and B7 - H4 in optic gliomas in children / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

AIM: To study the expressions and clinical significance of PDCD4 and B7-H4 in optic gliomas in children. METHODS:We used immunohistochemistry to evaluate the expressions of PDCD4 and B7-H4 in specimens from 52 optic gliomas in children cases, and analyzed the correlation of PDCD4 and B7 - H4 expression with clinicopathological factors children optic gliomas. RESULTS: PDCD4 expression reduced in optic glioma tissuePDCD4 expression rate in 52 cases of optic glioma tissues decreasing was correlated with tumor malignancy increase (P CONCLUSION: Expressions of PDCD4 and B7-H4 may be clinically relevant to tumor malignancy of optic gliomas in children and prevention of metastasis and prediction of prognosis.