Review of the potential use of blood neuro-biomarkers in the diagnosis of mild traumatic brain injury
Clinical and Experimental Emergency Medicine
;
(4): 121-127, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-645332
ABSTRACT
Head injury is a common presenting complaint amongst emergency department patients. To date, there has been no widespread utilization of neuro-biomarkers to aid the diagnosis of traumatic brain injury. This review article explores which neuro-biomarkers could be used in the emergency department in aiding the clinical diagnosis of mild traumatic brain injury. Based on the available evidence, the most promising neuro-biomarkers appear to be Glial fibrillary acidic protein (GFAP) and Ubiquitin C-Terminal Hydrolase Isozyme L1 (UCH-L1) as these show significant rises in peripheral blood levels shortly after injury and these have been demonstrated to correlate with long-term clinical outcomes. Treatment strategies for minor traumatic brain injury in the emergency department setting are not well developed. The introduction of blood neuro-biomarkers could reduce unnecessary radiation exposure and provide an opportunity to improve the care of this patient group.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Concussão Encefálica
/
Lesões Encefálicas
/
Biomarcadores
/
Exposição à Radiação
/
Ubiquitina Tiolesterase
/
Diagnóstico
/
Serviço Hospitalar de Emergência
/
Proteína Glial Fibrilar Ácida
/
Traumatismos Craniocerebrais
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Clinical and Experimental Emergency Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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