Alterations of Glutamate and GABA Immunoreactivities in the Anterior Horn of the Ischemic Spinal Cord of the Rabbit / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 589-597, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-645820
ABSTRACT
PURPOSE:
This study was carried out to investigate chronological changes of glutamate and gamma-aminobutyric acid (GABA) immunoreactivities in the anterior horn of the spinal cord after ischemia-reperfusion. MATERIALS ANDMETHODS:
Spinal cord ischemia was induced by clamping the abdominal aorta for 15 minutes in New Zealand white rabbit, and then the spinal cord was reperfused. These animals were sacrificed at 0.5, 1, 3, 6, 12, 24 and 48 hours after ischemia-reperfusion. Spinal cord sections at the level of L7 were immunostained against glutamate and GABA.RESULTS:
Glutamate immunoreactive neurons and fibers were first detected in the lamina IX at 30 minutes, but at 1 hour, the immunoreactivity returned to the control level. At 6 hour, glutamate immunoreactivity was observed around the blood vessels and its immunoreactivity increased between 6 and 12 hour. Thereafter the immunoreactivity decreased and eventually disappeared at 48 hours. GABA immunoreactivity increased in the anterior horn from 6 to 12 hours. Thereafter, GABA immunoreactivity decreased and eventually disappeared at 48 hours.CONCLUSION:
These results suggest that the alteration of the glutamate immunoreactivity may occur much rapidly than that of GABA immunoreactivity in spinal anterior horn after ischemia-reperfusion.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Aorta Abdominal
/
Medula Espinal
/
Vasos Sanguíneos
/
Imuno-Histoquímica
/
Ácido Glutâmico
/
Constrição
/
Isquemia do Cordão Espinal
/
Ácido gama-Aminobutírico
/
Cornos
/
Neurônios
Limite:
Animais
País/Região como assunto:
Oceania
Idioma:
Coreano
Revista:
The Journal of the Korean Orthopaedic Association
Ano de publicação:
2004
Tipo de documento:
Artigo
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