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How Many Sentinel Lymph Nodes Are Enough for Accurate Axillary Staging in T1-2 Breast Cancer? / 한국유방암학회지
Journal of Breast Cancer ; : 296-300, 2011.
Artigo em Inglês | WPRIM | ID: wpr-64605
ABSTRACT

PURPOSE:

During a sentinel lymph node biopsy (SLNB) for breast cancer, the appropriate number of sentinel lymph nodes (SLNs) to be removed for accurate axillary staging is still controversial. We hypothesized that there might be an optimal threshold number of SLNs. We investigated how many SLNs should be removed to achieve an acceptable accuracy and ensure minimal morbidity.

METHODS:

We reviewed data of 328 patients with invasive breast cancer who underwent SLNB followed by complete level I and II axillary dissection between January 2004 and December 2005. The false negative rate (FNR) and accuracy of SLNB according to the number of removed SLNs were evaluated.

RESULTS:

The mean number of SLNs removed was 3.0 (range, 1-14), and that of total retrieved axillary lymph nodes was 17.5 (range, 10-40). In total, 111 (33.8%) patients had positive nodes on the permanent pathological report. Among them, 12 patients had negative SLNs; thus, the overall FNR of SLNB was 10.8% (12/111) and the accuracy was 96.3% (316/328). The FNR was 26.6% for a single SLN, 8.0% for two, and 11.1% for three. In cases where four or more SLNs were removed, the FNR decreased to 0% and accuracy reached 100%.

CONCLUSION:

Our data suggest that a SLNB should not only remove one or two of the hottest node(s) when other hot nodes exist. We also suggest that four might be an optimal threshold number of SLNs to be removed and that removal of more than four SLNs does not improve axillary staging accuracy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Piretrinas / Mama / Neoplasias da Mama / Sacarose Alimentar / Biópsia de Linfonodo Sentinela / Linfonodos / Nitrilas Limite: Humanos Idioma: Inglês Revista: Journal of Breast Cancer Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Piretrinas / Mama / Neoplasias da Mama / Sacarose Alimentar / Biópsia de Linfonodo Sentinela / Linfonodos / Nitrilas Limite: Humanos Idioma: Inglês Revista: Journal of Breast Cancer Ano de publicação: 2011 Tipo de documento: Artigo