Primary Non-Hodgkin's Lymphoma of the Larynx / 대한이비인후과학회지

ABSTRACT

Non-Hodgkin's lymphoma rarely involves the larynx. We retrospectively reviewed six patients with the diagnosis of lymphoma involving the larynx from January 1997 to December 2007. Fiberoptic examination showed diverse features involving the supraglottis. On histologic examination of the biopsy specimen, there were mucosa-associated lymphoid tissue lymphoma (MALT) in 2 cases, Mantle cell lymphoma in 2 cases, and NK/T cell lymphoma in 2 cases. In 4 cases, there was no systemic involvement by the lymphoma. These patients were treated with multiagent chemotherapy and radiotherapy and developed a complete response to therapy. But in one NK/T cell lymphoma patient, tumor recurrence was detected in nasopharynx after 3 years. In the other NK/T cell lymphoma patient, there was appendix involvement and he expired after 3 weeks in diagnosis. The early symptoms of laryngeal NHL are usually subtle and easily neglected. Early detection and aggressive therapy should be considered in laryngeal NHL