Proteomic Analysis of the Specific Protein Expression in Nasal Polyp / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 228-231, 2009.
Artigo
em Coreano
| WPRIM
| ID: wpr-646605
ABSTRACT
BACKGROUND AND OBJECTIVES:
Nasal polyp is a non-neoplastic, chronic inflammatory disease of the nasal mucosa, with its pathogenesis still not well known. We used proteomics, an emerging technique to identify new biomarkers in biological tissue, to find new potential biomarkers of the nasal polyp. MATERIALS ANDMETHOD:
The study materials consisted of 5 specimens of nasal polyp taken from 5 patients who underwent endoscopic sinus surgery and 5 cases of normal nasal mucosa of the inferior turbinate as control. We did the proteomic profiling using matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF MS).RESULTS:
We detected about 500 protein spots. The selected twelve spots were analyzed. Six up-regulated proteins are annexin, keratin, actin, serpin 3, glutathion S-transferase P, and coactosins like protein. Six down-regulated proteins are two vimentins, two actins, fibrinogen, and hemoglobin subunit beta.CONCLUSION:
We identified 12 proteins expressed in the nasal polyp by using proteomics. These proteins may be helpful in understanding the mechanism of the pathogenesis of nasal polyp, and may be used as basic data.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Conchas Nasais
/
Vimentina
/
Fibrinogênio
/
Hemoglobinas
/
Biomarcadores
/
Proteínas
/
Pólipos Nasais
/
Actinas
/
Proteômica
/
Queratinas
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
2009
Tipo de documento:
Artigo
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