Predictors for the Transition from Ductal Carcinoma In Situ to Invasive Breast Cancer in Korean Patients
Journal of Breast Disease
;
(2): 16-23, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-646620
ABSTRACT
PURPOSE:
To identify predictive factors of upstaging from diagnosed ductal carcinoma in situ (DCIS) to invasive cancer after surgical excision.METHODS:
One hundred seventy-four patients diagnosed with DCIS based on biopsies between January 2009 and December 2014 were evaluated. Patients' clinicopathological variables were assessed to identify predictive factors of invasive carcinoma from final pathology.RESULTS:
One hundred seventy-four cases of DCIS were included. Of these, 42 were upstaged to invasive carcinoma on the final excision. Preoperative features such as age 40 years or younger at diagnosis, presence of a palpable mass, ultrasonography (USG)-guided core needle biopsy, tumor size ≥20 mm on USG, high grade DCIS, cribriform DCIS, comedo necrosis, presence of intraluminal calcification, estrogen receptor negativity, progesterone receptor negativity and triple-negative subtype were significantly associated with the risk of invasive carcinoma. Multivariate analysis showed that a tumor size ≥20 mm on USG and triple negative subtype were independently associated with upstaging.CONCLUSION:
Tumor size ≥20 mm on USG and triple-negative subtype were independently associated with the upstaging of DCIS to invasive cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Biópsia
/
Mama
/
Neoplasias da Mama
/
Receptores de Progesterona
/
Análise Multivariada
/
Ultrassonografia
/
Carcinoma Intraductal não Infiltrante
/
Carcinoma Ductal
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Breast Disease
Ano de publicação:
2016
Tipo de documento:
Artigo
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