Stimulation of bone formation in the expanding inter-premaxillary suture by vitamin E, in rat / 대한치과교정학회지
Korean Journal of Orthodontics
; : 337-347, 2009.
Article
em En
| WPRIM
| ID: wpr-646721
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: The aim of this study was to evaluate the effects of vitamin E (alpha-tocopherol) administration on bone formation in response to expansion of the inter-premaxillary suture, in rats, histomorphometrically. METHODS: Thirty 50 - 60 day old Wistar rats were separated into five equal groups (one control and four experimental). All groups were subjected to inter-premaxilla expansion with 50-gram of force. Six control animals received saline solution (Group I) and three experimental groups were treated with a single dose of alpha-tocopherol injected into the inter-premaxillary suture after one day after appliance placement (Group II: 2 mg/kg; Group III: 10 mg/kg; and Group IV: 50 mg/kg). A further group of six animals received three injections of 10 mg/kg alpha-tocopherol, one each on days 3, 6, and 9 (Group V). Bone formation in the suture was evaluated by bone histomorphometry. Kruskal-Wallis rank and Mann-Whitney U tests were used for statistical evaluation at p<0.05 level. RESULTS: New bone area, bone perimeter, feret's diameter and newly formed bone measurements were significantly higher in the experimental groups than the control (p<0.001). Bone architecture in alpha-tocopherol administrated groups was improved, and bone formation during the expansion period was stimulated significantly, in a dose-dependent manner. CONCLUSIONS: The application of alpha-tocopherol during the early stages to orthopedically expanded inter-premaxillary suture areas may stimulate bone formation and shorten the retention period, in rats.
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WPRIM
Assunto principal:
Osteogênese
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Retenção Psicológica
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Suturas
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Vitamina E
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Vitaminas
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Cloreto de Sódio
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Ratos Wistar
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Alfa-Tocoferol
Limite:
Animals
Idioma:
En
Revista:
Korean Journal of Orthodontics
Ano de publicação:
2009
Tipo de documento:
Article