Microfluidic Spinning of the Fibrous Alginate Scaffolds for Modulation of the Degradation Profile
Tissue Engineering and Regenerative Medicine
;
(6): 140-148, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-646905
ABSTRACT
In tissue engineering, alginate has been an attractive material due to its biocompatibility and ability to form hydrogels, unless its uncontrollable degradation could be an undesirable feature. Here, we developed a simple and easy method to tune the degradation profile of the fibrous alginate scaffolds by the microfluidic wet spinning techniques, according with the use of isopropyl alcohol for dense packing of alginate chains in the microfiber production and the increase of crosslinking with Ca²⁺ ion. The degradation profiling was analyzed by mass losses, swelling ratios, and also observation of the morphologic changes. The results demonstrated that high packing density might be provided by self-aggregation of polymer chains through high dipole interactions between sheath and core fluids and that the increase of crosslinking rates could make degradation of alginate scaffold controllable. We suggest that the tunable degradation of the alginate fibrous scaffolds may expand its utilities for biomedical applications such as drug delivery, in vitro cell culture, wound healing, tissue engineering and regenerative medicine.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polímeros
/
Cicatrização
/
Técnicas In Vitro
/
Técnicas de Cultura de Células
/
2-Propanol
/
Hidrogéis
/
Engenharia Tecidual
/
Microfluídica
/
Medicina Regenerativa
/
Métodos
Idioma:
Inglês
Revista:
Tissue Engineering and Regenerative Medicine
Ano de publicação:
2016
Tipo de documento:
Artigo
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