Sensorinerual Hearing Loss Harboring a Mitochondrial DNA tRNA(Leu(UUR)) Point Mutation / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 1691-1695, 1997.
Artigo
em Coreano
| WPRIM
| ID: wpr-647280
ABSTRACT
It is well known that sensorineural heating loss(SNHL) may be frequently associated with mitochondrial DNA(mtDNA) mutations. Mitochondrial DNA mutations associated SNHL have previously described in aminoglycoside-induced hearing loss(A1553G in the mitochondrial 12S ribosomal RNA gene) and diabetes with hearing loss(A3243G in the mitochondrial transfer RNA(Leu(UUR)) gene. The authors report a case of SNHL and diabetes mellitus associated with mtDNA mutation(A3243G). Patient had adult-onset maternally inherited diabetes mellitus. The SNHL appeared to be in progess since adolescence and was bilateral and symmetric. Bilateral hearing was impaired in all frequencies and was deteriorated more severely at high frequencies. Audiometric test results suggested that hearing loss involved in the cochlear rather than the retrocochlear. The point mutation of mtDNA should be suspected in patients with progressive cochlear hearing loss when they also have a family history of diabetes and/or hearing impairment.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
DNA Mitocondrial
/
RNA Ribossômico
/
Mutação Puntual
/
Diabetes Mellitus
/
Audição
/
Perda Auditiva
/
Perda Auditiva Neurossensorial
/
Temperatura Alta
/
Calefação
Limite:
Adolescente
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
1997
Tipo de documento:
Artigo
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