Effects of D-003 (10 mg/day) on Bone Mineral Density of the Lumbar Spine and Femoral Neck in Postmenopausal Women: A Randomized, Double-Blinded Study
The Korean Journal of Internal Medicine
;
: 168-178, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-64777
ABSTRACT
BACKGROUND/AIMS:
Increased osteoclast activity is a pivotal finding in osteoporosis. This increase is mediated via the mevalonate-to-cholesterol pathway, which is involved in producing the intermediates required for osteoclast activity. D-003, a mixture of high molecular weight sugarcane wax acids, has been shown to inhibit cholesterol synthesis prior to mevalonate production, resulting in a reduction of bone loss and resorption in ovariectomized rats. Moreover, previous studies have demonstrated that short-term D-003 treatment reduces urinary excretion of deoxypyridinoline/creatinine in postmenopausal women.METHODS:
We performed a double-blinded, placebo-controlled study to investigate the effects of D-003 (10 mg/day) treatment for 3 years on bone mineral density (BMD) in 83 postmenopausal women with low BMD.RESULTS:
Over 3 years, D-003 treatment increased lumbar spine BMD (5.1%, p < 0.01) and improved osteoporosis-related quality of life scores as compared with placebo-treated controls. D-003 was also well tolerated; the frequency of adverse events in the bone, joints, or muscle with D-003 treatment (p < 0.05) was lower than in the placebo group.CONCLUSIONS:
D-003 treatment (10 mg/day) for 3 years increased lumbar spine BMD and produced clinical improvements in postmenopausal women with low BMD. Further studies, however, will be required to confirm these results.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Qualidade de Vida
/
Fatores de Tempo
/
Absorciometria de Fóton
/
Densidade Óssea
/
Osteoporose Pós-Menopausa
/
Método Duplo-Cego
/
Inquéritos e Questionários
/
Análise de Variância
/
Resultado do Tratamento
/
Cuba
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
País/Região como assunto:
Caribe
/
Cuba
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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