Effect of Hizikia Fusiforme Water Extracts on Mouse Immune Cell Activation
The Korean Journal of Nutrition
;
: 624-629, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-647925
ABSTRACT
Hizikia fusiforme (sea weed fusiforme) has long been used for food source in this country. This study was performed to evalute the immunomodulative effects of Hizikia fusiforme (sea weed fusiforme) in mouse, using in vivo experiments. In vivo experiment, different concentration (0, 50, 500 mg/kg B.W.) of Hizikia fusiforme water extracts were orally administrated into mouse every other day for two weeks. The proliferation of mouse splenocytes, the production of three cytokines (IL-1beta, IL-6, TNF-alpha) secreted by activated macrophage. Splenocyte proliferation was enhanced in mouse orally administrated with 50 mg/kg B.W. and 500 mg/kg B.W. concentration compared to that of control group. Especially, the highest proliferation of spleoncyte was seen from the mouse orally administrated at the concentration of 50 mg/kg B.W. Also, the mouse of Hizikia fusiforme water extracts supplementation group in the both concentrations showed enhanced levels of cytokine production by activated peritoneal macrophages compared to those in control group. The highest level of cytokine (IL-1beta, IL-6, TNF-alpha) production was observed at 50 mg/kg B.W. supplementation group with LPS stimulation in all cases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Água
/
Citocinas
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
/
Macrófagos Peritoneais
/
Macrófagos
Limite:
Animais
Idioma:
Coreano
Revista:
The Korean Journal of Nutrition
Ano de publicação:
2007
Tipo de documento:
Artigo
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