Expression of Tonicity-Responsive Enhancer Binding Protein (TonEBP) in the Rat Cochlea: An Immunohistochemical Study / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 439-444, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-648744
ABSTRACT
BACKGROUND AND OBJECTIVES:
The inner ear is an organ used for hearing and balance. For its normal function, the inner ear fluid homeostasis is required. There has been controversy over the regulatory mechanisms of maintaining inner ear fluid balance, and they have not yet been clearly defined. TonEBP is the protein that binds tonicity-responsive enhancer elements in the osmoprotective gene, which elevates the compatible osmolytes, which in turn induces cell survival in hypertonic condition. The aim of this study was to elucidate if there is an osmoregulatory mechanism in cochlea. Material andMethod:
The localization of TonEBP in the cochlea of male Sprague-Dawley rats was studied by immunohistochemistry with an anti rabbit polyclonal anti-rat TonEBP antibody.RESULTS:
TonEBP was expressed at outer hair cells, Deiter cells, spiral ligaments, sprial limbus connective tissues, and epithelial lining of basilar membrane facing scala tympani.CONCLUSION:
TonEBP in cochlea is one of the proteins involved in elucidating cell survival in changed tonicity during inner ear homeostasis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Rampa do Tímpano
/
Equilíbrio Hidroeletrolítico
/
Imuno-Histoquímica
/
Proteínas de Transporte
/
Sobrevivência Celular
/
Membrana Basilar
/
Elementos Facilitadores Genéticos
/
Ratos Sprague-Dawley
/
Cóclea
/
Tecido Conjuntivo
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
2002
Tipo de documento:
Artigo
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