A Case of Anti-Hu Associated Paraneoplastic Subacute Sensory Neuronopathy

ABSTRACT

Subacute sensory neuronopathy usually occurs as a paraneoplastic syndrome, occurring most frequently in small cell lung cancer. We report a 63-year-old male presenting typical symptoms of subacute sensory neuronopathy. Electrophysiologic studies showed diffuse sensory axonal degeneration and anti-Hu antibody was positive in his serum. We reevaluated pulmonary lesions formerly diagnosed as active pulmonary tuberculosis. Chest computed tomography showed two nodules and hilar lymphadenopathy, and by percutaneous needle biopsy, small cell lung cancer was diag-nosed.