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Hormonal Changes of the Brain-Dead Organ Donors: A 3-Year Experience / 대한구급학회지
The Korean Journal of Critical Care Medicine ; : 30-35, 2008.
Artigo em Inglês | WPRIM | ID: wpr-649974
ABSTRACT

BACKGROUND:

Success of transplantation is critically dependent upon the quality of the donor organ and optimal management. Recently, hormonal replacement therapy has been reported to result in rapid recovery of cardiac function and enable significantly more organs to be transplanted, while some other studies show conflicting results. The aim of this study is to comprehensively evaluate changes in basal circulating hormonal levels of the brain-dead organ donors.

METHODS:

We reviewed the records of all brain-dead patients between January, 2004, and June, 2007. Hemodynamic variables, plasma hormone levels were recorded at following time points admission to the ICU (T1, baseline), 30 minutes (min) after first apnea test (T2), 30 min after second apnea test (T3), before operation for harvesting (T4). Hormonal measurements included cortisol, adrenocorticotrophic hormone, triiodothyronine (T(3)), thyroxine, free thyroxine, thyroid-stimulating hormone, growth hormone, and testosterone.

RESULTS:

Nineteen patients were included in this study. Comparisons of hemodynamic parameters and hormonal levels to baseline values revealed no significant changes throughout the study period. When the patients were divided into 2 groups according to the requirement of norepinephrine (either>0.05 or 0.05microgram/kg/min of norepinephrine had T(3) level below the normal range at significantly more time points of measurement (7 vs. 0).

CONCLUSION:

In this comprehensive assessment of hormonal levels in brain-dead organ donors, we could not observe any significant changes during the ICU stay. Replacement therapy of T(3) may be considered in patients requiring >0.05microgram/kg/min of norepinephrine.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Apneia / Plasma / Valores de Referência / Testosterona / Tiroxina / Doadores de Tecidos / Tri-Iodotironina / Hidrocortisona / Hormônio do Crescimento / Tireotropina Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Critical Care Medicine Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Apneia / Plasma / Valores de Referência / Testosterona / Tiroxina / Doadores de Tecidos / Tri-Iodotironina / Hidrocortisona / Hormônio do Crescimento / Tireotropina Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Critical Care Medicine Ano de publicação: 2008 Tipo de documento: Artigo