Oral Proton Pump Inhibitor for Treatment of Congenital Chloride Diarrhea
Neonatal Medicine
;
: 59-63, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-64999
ABSTRACT
Congenital chloride diarrhea (CCD) is a rare autosomal recessive disease, which is characterized by electrolyte absorption defect due to impaired function of the Cl-/HCO3 - exchanger in the ileum and the colon. Its main features are profuse watery diarrhea, high fecal chloride concentration, and failure to thrive. Profuse watery diarrhea characterized by a high concentration of chloride in stools results in hypochloremia, hyponatremia, and dehydration with metabolic alkalosis. Early detection and therapeutic intervention can prevent life-threatening symptoms of CCD and growth failure. Recently, several therapies, such as proton pump inhibitors and butyrate, have been suggested for amelioration of diarrhea. Here, we report a case of CCD in a preterm male infant who was successfully treated with an oral proton pump inhibitor.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prótons
/
Omeprazol
/
Butiratos
/
Bombas de Próton
/
Colo
/
Desidratação
/
Diarreia
/
Absorção
/
Alcalose
/
Insuficiência de Crescimento
Tipo de estudo:
Estudo de rastreamento
Limite:
Humanos
/
Lactente
/
Masculino
Idioma:
Inglês
Revista:
Neonatal Medicine
Ano de publicação:
2016
Tipo de documento:
Artigo
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