Prevention of overt diabetes and insulitis by BCG administration in the NOD mice of the breast-fed period / 대한해부학회지
Korean Journal of Anatomy
;
: 49-54, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-650145
ABSTRACT
By the concept that IDDM (insulin-dependent diabetes mellitus) is one of the autoimmune diseases, several immune suppressive drugs and immune modulators including BCG have been used to suppress the occurrence of IDDM. A data reported that BCG has different effects for prevention of diabetes according to the timing of drug administration. This study was performed to examine the preventive effect of diabetes development and insulitis by administering BCG at breast-fed period. NOD (non-obese diabetic) mice were divided into three groups Group I, II, III were injected by BCG on the first day, eighth day, and twenty second day of life respectively. The later BCG was injected, the smaller occurrence of diabetes and the lower severity of insulitis were.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Autoimunes
/
Camundongos Endogâmicos NOD
/
Diabetes Mellitus Tipo 1
/
Mycobacterium bovis
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Anatomy
Ano de publicação:
2000
Tipo de documento:
Artigo
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