Temporal Inhibition of FGF Signal on Endoderm Formation during Early Xenopus laevis Embryogenesis / 대한해부학회지
Korean Journal of Anatomy
;
: 463-468, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-650740
ABSTRACT
Our previous results showed that FGF signaling, which is important for the mesoderm and neuroectoderm induction, should be blocked for the endoderm formation in Xenopus. Here, Xenopus embryos were collected according to the two time points of MBT or stage 10.5. FGF signal was blocked with SU5402, chemical inhibitor of FGF signal, in the stage-specific embryos, to understand the role of FGF signal during the endoderm formation in the stage-specific embryos. Embryos subjected with the blocking of FGF signal before stage 10.5 showed the expanded abdominal volume in which endodermal mass was increased about 2 times but abdominal organs were not found. The tissue recombinant experiment showed that mesodermal tissue was necessary for the differentiation of endoderm. Embryos subjected with the blocking of FGF signal after stage 10.5 showed that abdomen was not expanded, the neural tube was opened instead. Our data indicate that blocking of FGF signal before stage 10.5 may be necessary for the endoderm induction and signals from neighboring endoderm tissue and mesoderm are required for the endoderm differentiation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Xenopus
/
Xenopus laevis
/
Desenvolvimento Embrionário
/
Estruturas Embrionárias
/
Endoderma
/
Abdome
/
Placa Neural
/
Tubo Neural
/
Mesoderma
Limite:
Gravidez
Idioma:
Coreano
Revista:
Korean Journal of Anatomy
Ano de publicação:
2003
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS