Depression as an Inflammatory Disease / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 5-10, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-65091
ABSTRACT
Inflammation is an immune response engaged with the reciprocal interactions among the neural, endocrine and immune system. From this psychoneuroimmunological view, inflammation is one of important allostatic loads contributory to depression. Sickness behaviors in the inflammatory state share many parts of depressive symptoms and patients treated with cytokines for various illnesses are at increased risk of developing depression. The dysfunctions of cytokines and hypothalamic-pituitary-adrenal axis have been widely investigated to find out inflammatory responses. Inflammatory mediators such as cytokines, glucocorticoid and C-reactive protein affect the etiopathogenesis of depression via altered monoamine and glutamate neurotransmission, glucocorticoid receptor resistance and neurogenesis. Although inflammation is subtle and not easy to be detected in the wide population, it is basal pathophysiology and plays an important role at least to the vulnerable patients. From this perspectives, inflammatory markers may be useful in the diagnosis and prediction of treatment response, leading to the possibility of tailored treatments. Understanding depression as a kind of inflammatory disease would provide new opportunities for the psychiatry beyond monoamine theory.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vértebra Cervical Áxis
/
Proteína C-Reativa
/
Psiconeuroimunologia
/
Receptores de Glucocorticoides
/
Citocinas
/
Transmissão Sináptica
/
Ácido Glutâmico
/
Depressão
/
Alostase
/
Comportamento de Doença
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2013
Tipo de documento:
Artigo
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