The Effect of Caffeine on 3T3-L1 Adipocyte Differentiation : A Nutrigenomical Approach
The Korean Journal of Nutrition
;
: 649-655, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-652253
ABSTRACT
Nutrigenomics refers to research that investigates the interaction between nutrition and the human genome. Caffeine in tea and coffee is widely and routinely consumed by people. This study was performed to confirm the effect of caffeine treatment on the gene expression and cytokine profiling in 3T3-L1 adipocyte cells using microarray and protein array methodology. Treatment of caffeine in 3T3-L1 adipocyte cells increased expression of several genes related with obesity including adipocyte C1Q and collagen domain containing (ACDC), Adipsin (ADN), uncoupling protein 3 (UCP3), while glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is known as lipid storage enzyme, was decreased by caffeine treatment. Furthermore, cytokines, such as interleukin-3 (IL-3), interleukin-12 (IL-12), interleukin-13 (IL-13), granulocyte colony stimulating factor (GCSF), granulocyte macrophage colony stimulating factor (GM-CSF) and vascular endothelial growth factor (VEGF), were decreased in caffeine treated 3T3-L1 adipocyte cells. These results provided interesting information about the genes related with caffeine and cytokine expression profiling in obesity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxirredutases
/
Chá
/
Cafeína
/
Fator D do Complemento
/
Expressão Gênica
/
Genoma Humano
/
Citocinas
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Colágeno
/
Fatores Estimuladores de Colônias
Limite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Nutrition
Ano de publicação:
2005
Tipo de documento:
Artigo
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