The Clinical Significance of VEGF and TGF-beta Expression in Osteosarcoma / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 519-525, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-652258
ABSTRACT
INTRODUCTION:
The transforming growth factor-beta (TGF-beta ) is a multipotent glycoprotein that has been implicated in tumor development. The vascular endothelial growth factor (VEGF), which is an endothelial-specific mitogen that is overexpressed in various malignancies, is believed to be a potent regulator of angiogenesis. Osteosarcoma was examined to determine firstly, if VEGF and the TGF-beta isoform were overexpressed in this sarcoma, and secondly, if the degree of expression might represent a significant biologic predictor for disease-specific survival. MATERIALS ANDMETHODS:
Selected paraffin-embedded tissues of surgical specimens from 25 patients of prechemotherapy case with osteosarcoma, who were treated between 1995 and 2001 were stained with rabbit polyclonal anti-VEGF and TGF-beta isoform antibodies.RESULTS:
The majority of high-grade osteosarcomas in this study had a high intensity TGF-beta 2, - 3 and VEGF expression levels. The three in 5 patients who died of the disease had a high VEGF expression level. However VEGF expression was only independent predictor of overall survival.CONCLUSION:
Further studies about TGF-beta and VEGF may provide useful information for understanding of pathophysiology of osteosarcoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sarcoma
/
Imuno-Histoquímica
/
Glicoproteínas
/
Osteossarcoma
/
Fator de Crescimento Transformador beta
/
Fator A de Crescimento do Endotélio Vascular
/
Anticorpos
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
The Journal of the Korean Orthopaedic Association
Ano de publicação:
2003
Tipo de documento:
Artigo
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