Early Experience With Active Surveillance in Low-Risk Prostate Cancer Treated
Korean Journal of Urology
;
: 167-171, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-65244
ABSTRACT
PURPOSE:
This study was conducted to describe our early experience with active surveillance (AS). MATERIALS ANDMETHODS:
Between January 2008 and December 2012, 35 patients were treated with AS. Selection criteria included the following Gleason score < or =6 with single positive core, clinical stage < or =T1c, prostate-specific antigen (PSA) < or =10 ng/mL, and unremarkable imaging results. On patient follow-up, we regularly measured PSA (every 3-6 months) and performed prostate biopsies (after 1 and 3 years).RESULTS:
In the first year of follow-up, prostate biopsies were performed in 25 patients (13 patients, negative for cancer; 7 patients, Gleason score of 6 without progression; 5 patients, progression, treated with radical prostatectomy [RP]). In the third year of follow-up, prostate biopsies were performed in five patients (two patients, negative for cancer; one patient, Gleason score of 6 without progression; two patients, progression, treated with RP). Seven patients discontinued AS because of increased anxiety, and three patients were lost to follow-up. Overall, seven patients (28%) who experienced progression had a mean PSA doubling time (DT) of 7.54 years. Six patients had a PSA DT of more than 3 years, whereas one had a PSA DT of less than 3 years. This study was limited by its small sample size and short follow-up period.CONCLUSIONS:
PSA kinetics did not correlate with progression, which suggests that regular biopsies should still be performed. AS is an available treatment option for patients with a low risk of prostate cancer but should only be used in carefully selected patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ansiedade
/
Próstata
/
Prostatectomia
/
Neoplasias da Próstata
/
Biópsia
/
Biópsia por Agulha
/
Cinética
/
Seguimentos
/
Antígeno Prostático Específico
/
Tamanho da Amostra
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Urology
Ano de publicação:
2014
Tipo de documento:
Artigo
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