Distribution of Beta-Catenin Expression in Adenoid Cystic Carcinoma of the Head and Neck / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 188-192, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-652523
ABSTRACT
BACKGROUND AND OBJECTIVES:
beta-catenin has functions in cell-cell adhesion with a complex of proteins that link cadherin to the cortical actin cytoskeleton and signal transduction through wnt developmental pathway. In this study, we investigated the distribution of beta-catenin in adenoid cystic carcinoma according to the histologic subtypes, perineural invasion, T classification, nodal status and stage. MATERIALS ANDMETHODS:
Each formalin-fixed paraffin-embedded surgical specimens were obtained from seventeen patients with adenoid cystic carcinoma. We performed immunohistochemical staining with beta-catenin monoclonal antibodies and compared its staining patterns with patients' clinical characteristics.RESULTS:
In tubular subtype, there were intense membranous staining pattern than other subtypes (p0.05).CONCLUSIONS:
It is suggest that there are mixed functional roles of beta-catenin in adenoid cystic carcinoma in tumor aggressiveness.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Citoesqueleto de Actina
/
Imuno-Histoquímica
/
Transdução de Sinais
/
Tonsila Faríngea
/
Classificação
/
Carcinoma Adenoide Cístico
/
Citoplasma
/
Beta Catenina
/
Cabeça
/
Anticorpos Monoclonais
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
2000
Tipo de documento:
Artigo
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