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Cutaneous peripheral nerve sheath tumors in 15 dogs / 대한수의학회지
Korean Journal of Veterinary Research ; : 7-12, 2014.
Artigo em Inglês | WPRIM | ID: wpr-65257
ABSTRACT
Peripheral nerve sheath tumors (PNSTs) are heterogeneous tumor groups of peripheral nerves that originate from either Schwann cells or modified Schwann cells, fibroblasts, or perineural cells. In this study, signalment and clinical data such as tumor location and size were evaluated for 15 cases of PNSTs collected from local animal hospitals. The mean age of dogs with malignant PNST was higher than that of dogs with benign PNST. Additionally, the male to female ratio in dogs with PNST was 1 4. In dogs with PNST, the primary sites of involvement were the hindlimb, forelimb, around the mammary glands, the neck, and the abdomen. Histiopathologic examination revealed that eight PNSTs were benign and seven were malignant. The tumor cells were composed of loosely to densely arranged interlacing bundles and wavy spindle cells arranged in short bundles, palisading, and whirling. High mitotic figures, local invasion, multifocal necrosis and atypical multinucleated giant cells were observed in malignant PNST cases. All PNSTs showed immunoreactivity for vimentin and S-100. However, only 93.3% and 73.3% were immunoreactive for NSE and GFAP, respectively. Overall, these results indicated that immunohistochemical markers such as vimentin, S-100 and NSE could help confirm the diagnosis of canine PNSTs.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Nervos Periféricos / Células de Schwann / Vimentina / Imuno-Histoquímica / Células Gigantes / Neoplasias de Bainha Neural / Glândulas Mamárias Humanas / Diagnóstico / Abdome / Fibroblastos Tipo de estudo: Estudo diagnóstico Limite: Animais / Feminino / Humanos / Masculino Idioma: Inglês Revista: Korean Journal of Veterinary Research Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Nervos Periféricos / Células de Schwann / Vimentina / Imuno-Histoquímica / Células Gigantes / Neoplasias de Bainha Neural / Glândulas Mamárias Humanas / Diagnóstico / Abdome / Fibroblastos Tipo de estudo: Estudo diagnóstico Limite: Animais / Feminino / Humanos / Masculino Idioma: Inglês Revista: Korean Journal of Veterinary Research Ano de publicação: 2014 Tipo de documento: Artigo