Expression of FGF-R and TGF-R in the Lateral Wall of the Guinea Pig / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 547-551, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-653208
ABSTRACT
BACKGROUND AND OBJECTIVES:
The endolymph produced from cochlear lateral wall regulates fluid balance and maintains positive endocochlear potentials. Although many immunohistochemical studies on ion transport enzymes have been reported, their mechanisms are still not completely understood. And there are no reports on the distribution of receptor tyrosine kinases in the cochlear lateral wall of the guinea pig. The purpose of this study is to evaluate the expression of the fibroblast growth factor receptor (FGFR) and transforming growth factor receptor-beta (TGFR-beta, type II) in the lateral wall of the guinea pig cochlea. MATERIALS ANDMETHODS:
We investigated the immunohistochemical localization of the receptor tyrosine kinases (FGFR, TGFR-beta) in the lateral wall of the Preyer's positive, pigmented guinea pig.RESULTS:
The results showed that receptor tyrosine kinases were expressed in the cytoplasm of the marginal cells, intermediate cells in the stria vascularis, and type II, III, IV, and V fibrocytes, but not the basal cells and type I fibrocytes, in the lateral wall of the guinea pig.CONCLUSION:
The findings suggest that receptor tyrosine kinases are involved in the various ion transports and that they participate in the PLC-IP(3) second messenger system.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfotransferases
/
Estria Vascular
/
Tirosina
/
Equilíbrio Hidroeletrolítico
/
Sistemas do Segundo Mensageiro
/
Transdução de Sinais
/
Fatores de Crescimento Transformadores
/
Guiné
/
Receptores de Fatores de Crescimento de Fibroblastos
/
Transporte de Íons
Limite:
Animais
País/Região como assunto:
África
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
1999
Tipo de documento:
Artigo
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