Oral Microbiome and Its Association with Oral Diseases / 대한이비인후과학회지

ABSTRACT

Microbiome means a holistic genomic information of microorganism which usually having symbiotic relationships confer benefits to human body. Breaches in the homeostasis between host and microorganism or alterations of the microbiome are well-known risk factors promoting human diseases. Oral cavity has hundreds of microbes and demonstrates chronic inflammatory conditions by interrelations among microorganisms, foreign bodies, alcohol, and smoking. Oral microbiome also demonstrates a growing evidence of its implication in the etiology of oral diseases including cancer and other systemic diseases. In this review paper, I would introduce to the associated human diseases with oral microbiome and the mechanism how changes in the oral microbiome with its microenvironment leads to the host diseases. And I would also suggest a new research field in otorhinolaryngology connected to oral microbiome.