Light and Scaning Electromicroscopic Study on the Experimental on the Experimental Endolymphatic Hydrops in Guinea Pigs / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 1715-1721, 1997.
Artigo
em Coreano
| WPRIM
| ID: wpr-653759
ABSTRACT
BACKGROUND:
Despite numerous investigations, the pathogenesis of Meniere's disease is uncertain. Endolymphatic hydrops (ELH) has been the main histologic finding of Meniere's disease. Experimentally induced ELH in animal model has been developed in order to understand better the consequences of this morphopathology on inner ear structure and function.OBJECTIVES:
The aim of this study is to develope the animal model of ELH. MATERIAL ANDMETHODS:
We made an animal endolymphatic hydrops model on giunea pigs by mechanically obliterating the right endolympatic sac and duct. The left ears were used as a controls.RESULTS:
After twelve weeks, the temporal bones were prepared for light and electron microscopic examination. The light microscopic study showed the distension and folding of Reissner's membrane, however other pathologic changes were uncertain in hydropic aminal. Under scanning electron microscopic examination, the cellular population of Reissner membrane remained normal but the microvilli of Reissner membrane were significantly decreased in hydrops group. The damage pattern of stereocilia were most severe in the apical turns, followed by the middle and the basal turns, in the order of severeity. The outer hair cell third row was most severely damaged in the entire cochlea, whereas the outer hair cell first row was relatively spared. On the single hair cell examination, abnormal distensions of the tip of stereocilia started from longer stereocilia. The number of microvilli on marginal cell was reduced in stria vascularis, but atrophic change was not observed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estria Vascular
/
Suínos
/
Osso Temporal
/
Guiné
/
Cóclea
/
Hidropisia Endolinfática
/
Modelos Animais
/
Orelha
/
Edema
/
Estereocílios
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
País/Região como assunto:
África
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
1997
Tipo de documento:
Artigo
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