CHD1L Is a Marker for Poor Prognosis of Hepatocellular Carcinoma after Surgical Resection
Korean Journal of Pathology
;
: 9-15, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-65415
ABSTRACT
BACKGROUND:
The gene for chromodomain helicase/ATPase DNA binding protein 1-like (CHD1L) was recently identified as a target oncogene within the 1q21 amplicon, which occurs in 46% to 86% of primary hepatocellular carcinoma (HCC) cases. However, the prognostic significance of CHD1L in HCC remains uncertain. In this study, we investigated the roles of CHD1L in the prognosis of HCC.METHODS:
We investigated the expressions of CHD1L in tumor tissue microarrays of 281 primary HCC patients who underwent surgical resection using immunohistochemistry. Prognostic factors of HCC were examined by univariate and multivariate analyses. The median follow-up period was 75.6 months.RESULTS:
CHD1L expression was observed in 48 of the 281 HCCs (17.1%). CHD1L expression was associated with a younger age (p=0.033), higher Edmondson grade (p=0.019), microvascular invasion (p<0.001), major portal vein invasion (p=0.037), higher American Joint Committee on Cancer T stage (p=0.001), lower albumin level (p=0.047), and higher alpha-fetoprotein level (p=0.002). Multivariate analyses revealed that CHD1L expression (p=0.027), Edmondson grade III (p=0.034), and higher Barcelona Clinic Liver Cancer stage (p<0.001) were independent predictors of shorter disease-free survival.CONCLUSIONS:
CHD1L expression might be a prognostic marker of shorter disease-free survival in HCC patients after surgical resection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oncogenes
/
Veia Porta
/
Prognóstico
/
Imuno-Histoquímica
/
Alfa-Fetoproteínas
/
Análise Multivariada
/
Seguimentos
/
Carcinoma Hepatocelular
/
Intervalo Livre de Doença
/
Proteínas de Ligação a DNA
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Pathology
Ano de publicação:
2013
Tipo de documento:
Artigo
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