Therapeutic Effects of 0.03% Tacrolimus Eye Drops for Chronic Ocular Graft-Versus-Host Disease
Journal of the Korean Ophthalmological Society
;
: 1505-1510, 2015.
Artigo
em Coreano
| WPRIM
| ID: wpr-65433
ABSTRACT
PURPOSE:
To evaluate the therapeutic effects of 0.03% tacrolimus eye drops on dry eye associated with chronic ocular graft-versus-host disease (GVHD).METHODS:
This study included 24 eyes of 12 patients with refractory dry eye associated with chronic ocular GVHD who were unresponsive to topical steroid and 0.05% topical cyclosporine. The topical steroid and cyclosporine were discontinued for 2 weeks before treatment and 0.03% tacrolimus eye drops were applied twice a day for 1 month. Artificial tears, ointment, and lid cleanser were used in the same manner before initiating tacrolimus treatment. Ocular staining score, tear break-up time, ocular surface disease index (OSDI), and Schirmer I test score were evaluated.RESULTS:
Ocular staining score, tear break-up time, and OSDI improved with statistical significance (p < 0.05) after 28 days of treatment. Schirmer I test did not show statistical improvement after treatment.CONCLUSIONS:
The use of 0.03% tacrolimus eye drops were effective for refractory dry eye associated with chronic ocular GVHD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Soluções Oftálmicas
/
Lágrimas
/
Tacrolimo
/
Ciclosporina
/
Doença Enxerto-Hospedeiro
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
2015
Tipo de documento:
Artigo
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