Mechanisms of Lymph Node Metastasis in Head and Neck Cancer / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 259-264, 2016.
Artigo
em Coreano
| WPRIM
| ID: wpr-654497
ABSTRACT
Lymph node metastasis (LNM) is an important prognostic factor in head and neck cancer (HNC), which leads to recurrence and poor outcome. Despite the advances in multimodality treatment protocols, overall survival in patients with LNM remains limited, thus calling for the need of a more thorough understanding of the biology in metastatic process. In the past, LNM had been suspected to rely mostly on passive mechanistic impulse from primary tumor. However, recent discovery of new lymphatic markers, regulating growth factors, and cognate receptors, has elucidated the active biological regulation during metastatic cascades, which primarily involves primary tumor lymphangiogenesis, pre-metastatic niche formation, and sentinel LNM. In this review, we discuss recent literatures on the mechanisms of LNM in HNC that is expected to allow a better understanding of the disease as well as suggesting a potential clinical implication.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Biologia
/
Protocolos Clínicos
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Linfangiogênese
/
Cabeça
/
Neoplasias de Cabeça e Pescoço
/
Linfonodos
/
Metástase Linfática
/
Metástase Neoplásica
Tipo de estudo:
Guia de Prática Clínica
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
2016
Tipo de documento:
Artigo
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