Protective Effect of Procaine Hydrochloride on Cisplatin Induced Ototoxicity in Guinea Pig / 대한이비인후과학회지

ABSTRACT

BACKGROUND AND OBJECTIVES: The use of cisplatin is limited by dose-dependent nephrotoxicity, ototoxicity. Some papers demonstrated that procaine hydrochloride increases the therapeutic index of cisplatin, reducing nephrotoxicity, improving antitumor activity. The purpose of this study was to evaluate the preventive effect of procain hydrochloride on cisplatin induced ototoxicity. MATERIALS AND METHOD: Procaine hydrochloride was used to prevent the ototoxic effects of cisplatin. To evaluate the efficacy, ABR threshold shifts and histopathologic examinations were performed. RESULTS: After injection of cisplatin, ABR indicated that procaine hydrochloride reduced threshold shift significantly. The cochlear hair cells, especially outer hair cells in basal turn, were severely damaged in cisplatin treated group comparing to cisplatin/procaine hydrochloride treated group. In cisplatin/ procaine hydrochloride treated cochlea, the apoptotic cells were decreased compared to cisplatin treated group. CONCLUSION: Procaine hydrochloride might protect cisplatin induced ototoxicity in guinea pigs.