Clinical Experiences of Diagnosis and Treatment for Wegener's Granulomatosis / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 1109-1118, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-655758
ABSTRACT
BACKGROUND AND OBJECTIVES:
Because most patients with Wegener's granulomatosis (WG) visit otolaryngologists complaining of head and neck symptoms, otolaryngologists may play an important role in early diagnosis. In this study, we investigated clinical features, laboratory findings and treatment outcomes of 33 patients with WG, and propose a new algorithm for the diagnosis of WG. SUBJECTS ANDMETHOD:
Thirty-three patients with WG who visited the clinic between January 1980 and December 2007 were included. The medical records of 13 male and 20 female patients were retrospectively reviewed. The mean follow-up duration was 68 months.RESULTS:
Most WG patients had ENT symptoms such as nasal obstruction, rhinorrhea, otorrhea, hearing loss, dyspnea and hoarseness. The mean duration from ENT examination to diagnosis was 6.7 months (3 days- 102 months) and tissue biopsy was performed on an average of 2.1 times to confirm the diagnosis. While 16 patients could be diagnosed by the first biopsy, the others were required to repeat the biopsy. ANCA was positive in 17 patients (50%). Twentysix patients (78.7%) had multiple organ involvements such as lung, kidney, joint and skin. Twenty-eight patients received a combination of prednisolone and cyclophosphamide with the remission rate of 87%.CONCLUSION:
Based on this study, we propose a better algorithm for the diagnosis of WG to avoid unnecessary delay in the diagnosis and treatment of WG.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Biópsia
/
Prednisolona
/
Obstrução Nasal
/
Granulomatose com Poliangiite
/
Rouquidão
/
Prontuários Médicos
/
Estudos Retrospectivos
/
Seguimentos
/
Anticorpos Anticitoplasma de Neutrófilos
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
2008
Tipo de documento:
Artigo
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