An Effect of Ginkgo Extract on Salicylate Ototoxicity in Guinea Pigs / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 970-975, 1997.
Artigo
em Coreano
| WPRIM
| ID: wpr-655946
ABSTRACT
BACKGROUND:
The mechanism of salicylate ototoxicity is probably related to reversible biochemical or metabolic changes in the cochlea. Decreased cochlear blood flow seems to play an important role in salicylate ototoxicity. Several constituents of ginkgo extract have the action of increasing blood flow, antagonism of platelet activating factor and scavenger of free radicals. It might be thought that these activities of ginkgo extract could contribute to attenuate salicylate ototoxicity.OBJECTIVES:
Whether the salicylate induced hearing loss could be attenuated by pretreatment with ginkgo extract. MATERIALS ANDMETHODS:
Auditory brainstem response threshold changes were observed after the intramuscular injection of lysine salicylate(300mg/kg), or lysine salicylate with EGb 761(100mg/kg, single IP or 100mg/kg and 50mg/kg, IP, two times) pretreatment in each group of guinea pig.RESULTS:
In the groups with Ginkgo extract pretreatment, the threshold changes were less severe and recovered earlier than in group with salicylate injection only(p<0.05).CONCLUSIONS:
EGb 761 could attenuated the hearing loss after the injection of salicylate in guinea pig.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fator de Ativação de Plaquetas
/
Potenciais Evocados Auditivos do Tronco Encefálico
/
Guiné
/
Cóclea
/
Ginkgo biloba
/
Radicais Livres
/
Cobaias
/
Perda Auditiva
/
Injeções Intramusculares
/
Lisina
Limite:
Animais
País/Região como assunto:
África
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
1997
Tipo de documento:
Artigo
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