Expression and Distribution of Tumor Necrosis Factor-Alpha in Mice Cochlea Exposed to Noise / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 527-533, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-656017
ABSTRACT
BACKGROUND AND OBJECTIVES:
Recent studies have shown that inflammatory responses occur in the inner ear under various damaging conditions including noise-overstimulation.Identification of time-dependent expression patterns of pro-inflammatory cytokines during the response initiation should lead to rational therapeutic strategies that block the response and reduce the damaging sequelae. MATERIALS ANDMETHOD:
We evaluated the time-dependent expression pattern of pro-inflammatory cytokines in noise-exposed mouse cochlea (white noise, 120 dB SPL, 3 hours) using immunohistochemistry and reverse transcriptase-polymerase chain reaction(RT-PCR).RESULTS:
The most potent pro-inflammatory cytokine, the tumor necrosis factor-alpha (TNF-alpha), was up-regulated after noise exposure. Immunohistochemical analyses showed that the TNF-alpha expression was distinctively induced within the spiral ganglion and stria vascularis. RT-PCR showed that TNF-alpha was induced shortly after noise exposure and persisted upto seven days following noise exposure.CONCLUSION:
Taken together, acoustic trauma induces cochlear inflammation and the data suggest that TNF-alpha may have some role in cochlea damage that occur following noise exposure.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Estria Vascular
/
Imuno-Histoquímica
/
Gânglio Espiral da Cóclea
/
Citocinas
/
Fator de Necrose Tumoral alfa
/
Cóclea
/
Perda Auditiva Provocada por Ruído
/
Inflamação
/
Orelha Interna
/
Ruído
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
2010
Tipo de documento:
Artigo
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