Activation of Nuclear Factor-kappaB in the Atherosclerotic Human Coronary Artery / 대한해부학회지
Korean Journal of Anatomy
;
: 111-118, 2006.
Artigo
em Coreano
| WPRIM
| ID: wpr-656237
ABSTRACT
Paraffin sections of atherosclerotic vessels were classified into initial lesion, preatheroma and complicated severe lesion by classification method from American Heart Association. Activation of NF-kappaB was hardly detectable in the initial atherosclerotic lesion. In the preatheroma, activated NF-kappaB was enhanced in the neointimal smooth muscle cells and macrophages in the lipid core. In contrast, activated NF-kappaB increased markedly in the neointimal and medial smooth muscle cells in the severe atherosclerotic vessel wall. However, in the severe lesion, NF-kappaB activation was diminished in the macrophages of lipid core. Our findings show that NF-kappaB was activated in the smooth muscle cells with the progression of atherosclerosis in the human coronary artery.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Parafina
/
NF-kappa B
/
Classificação
/
Vasos Coronários
/
Miócitos de Músculo Liso
/
Aterosclerose
/
American Heart Association
/
Macrófagos
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anatomy
Ano de publicação:
2006
Tipo de documento:
Artigo
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