Histologic Changes of Vocal Fold Aging in a Rat Model / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 506-510, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-656501
ABSTRACT
BACKGROUND AND OBJECTIVES:
Aging causes atrophy in mucosa of vocal folds, resulting in various deleterious changes in phonation. Eventually, these changes impair an elderly individual's ability to communicate with others and affect their quality of life. This investigation was carried out to determine the morphological characteristics of vocal folds in two different aged groups of rats, and to perform a validation of a rat model of age-related changes in larynx. SUBJECTS ANDMETHOD:
Larynges were obtained from 12 rats, of which 6 rats were 6 months old and the others 18 months old. The middle portion of each vocal folds were stained with haematoxylin and eosin (H&E), Masson's trichrome (MT), Alcian blue (AB) and compared.RESULTS:
Extracellular matrix in lamina propria of vocal folds presented lower density in 18 months-old rats than in 6 months-old rats (p<0.05). Also more severe fibrosis was observed in 18 months-old rats than in 6 months-old rats (p<0.05). Six months-old rats showed higer concentration of hyaluronic acid than did 18 months-old rats (p<0.05).CONCLUSION:
Aged vocal folds showed increased fibrosis and decreased density of collagen and hyaluronic acids in the lamina propria compared to young vocal fold.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fonação
/
Qualidade de Vida
/
Atrofia
/
Prega Vocal
/
Fibrose
/
Envelhecimento
/
Colágeno
/
Amarelo de Eosina-(YS)
/
Azul Alciano
/
Matriz Extracelular
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
2013
Tipo de documento:
Artigo
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