Allele Distribution of Human Surfactant Protein A in Otitis Media with Effusion / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 1145-1150, 2006.
Artigo
em Coreano
| WPRIM
| ID: wpr-656562
ABSTRACT
BACKGROUND AND OBJECTIVES:
Surfactant protein A (SP-A) which plays a role in the innate host defense of lung is also expressed in Eustachian tube. However the genes underlying the susceptibility to otitis media with effusion (OME) are known insufficiently. The current study attempts to evaluate the difference in the allele distribution of SP-A1 and SP-A2 between normal subjects and subjects with otitis media with effusion. SUBJECTS ANDMETHOD:
PCR-cRFLP-based methodology was used to detect SP-A genotypes in the 38 children with OME, and in the 55 normal newborns for control.RESULTS:
The frequencies of specific genotypes such as 6A(2), 1A(2) were increased in OME group, but the frequency of 6A3 was increased in control group.CONCLUSION:
It is presumed that SP-A alleles may be inductive (6A(2), 1A(2)) or protective (6A(3)) factors for OME. Specific genoytypes of SP-A may be an important determinant for the predisposition to OME.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Otite
/
Otite Média
/
Otite Média com Derrame
/
Proteína A Associada a Surfactante Pulmonar
/
Alelos
/
Tuba Auditiva
/
Genótipo
/
Pulmão
Limite:
Criança
/
Humanos
/
Recém-Nascido
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Ano de publicação:
2006
Tipo de documento:
Artigo
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