The value of nuclear matrix protein 22, cytokeratin 20 and survivin mRNA as diagnostic markers for bladder tumor / 国际检验医学杂志
International Journal of Laboratory Medicine
;
(12): 2551-2553, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-658464
ABSTRACT
Objective To investigate the value of nuclear matrix protein 22(NMP22),cytokeratin 20(CK20) and survivin mRNA in the diagnosis of bladder cancer.Methods The research enrolled 107 cases with hematuresis or irritation sign of bladder,who were divided into the control group(44 cases) and the observed group(63 cases).Besides,45 health volunteers were chose as the health group.The urine level of NMP22 was detected by ELISA,and CK20 and survivin mRNA by RT-PCR to evaluate the value in the diagnosis of bladder tumor The sensitivities and specificities of NMP22,CK20 and survivin mRNA were compared and analyzed.Results The urine level of NMP22 in the observed group(37.92 U/mL) was obviously higher than that of health volunteers (4.31 U/mL) and the control group(7.04 U/mL).The difference was significant(P<0.05).The sensitivity and specificity of NMP22 were 82.54% and 61.36% respectively,which was unrelated with the tumor stage.The sensitivities and specificities of CK20 and survivin mRNA were 83.70%,63.64% and 85.71%,90.91% respectively,which was positively related with the tumor stage.The sensitivities of CK20 and survivin mRNA in the T2-T4 subgroup were higher than that T1s-T1 subgroup.And there was statistic difference(P<0.05).Conclusion There are significant evidences that the detections of NMP22,CK20 and survivin mRNA as non-invasive measures could be better methods and higher sensitivity and specificity in diagnosing bladder cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
International Journal of Laboratory Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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