Research advances in the sphingosine kinase signaling pathway in liver fibrosis / 临床肝胆病杂志

ABSTRACT

Formation of liver fibrosis mainly involves activation of hepatic stellate cell and imbalance between synthesis and degradation of extracellular matrix.The sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P)/sphingosine 1-phosphate receptors (S1PRs) signaling pathway plays an important role in the regulation of cell life activities including proliferation,migration,and inflammatory response.This article introduces the distribution and biological functions of SphK,S1 P,and S1PRs and elaborates on the research advances in mechanism of action of the SphK/S1P/and S1PRs signaling pathway in liver fibrosis.Many studies have confirmed the important role of the SphK/S1P/and S1PRs signaling pathway in liver fibrosis,and in-depth exploration helps to provide new thoughts for clinical treatment of liver fibrosis and development of new drug targets.