Analysis of clinicopathologic characteristics, misdiagnosis and missed diagnosis of 4 malakoplakia cases / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 873-875, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-659014
ABSTRACT
Objective:
To analyze the pathogenesis, clinicopathological characteristics, diagnosis, and treatment of the malakoplakia for the purpose of avoiding misdiagnosis and missed diagnosis.Methods:
Clinicopathological features of four malakoplakia patients admit-ted to the Shanxi Cancer Hospital from March 2007 to March 2017 were studied by light microscopy, immunohistochemistry, and spe-cific stain technology, combining with a review of literature.Results:
The onset age of the 4 patients (two males and two females) ranged 56-76 years (median63 years). Two patients had malakoplakia in bladder;one patient had malakoplakia in bilateral ureters;and one case had malakoplakia in right pelvic. One patient has a history of systematic lupus erythematosis and diabetes. Malakoplakia is characterized by the accumulation of foam cells and concentrically-layered basophilic inclusions called Michaelis-Gutmann (M-G) bodies. The foam cells were positive for CD68 and PGM-1 by immunohistochemistry, indicating its derivation from the histocyte. M-G bodies were positive for periodic acid-Schiff reaction, iron, and calcium by specific staining technology.Conclusion:
Malakoplakia is a rare inflammatory condition and a common urinary tract disease, but it may involve any organ with non-specific symptoms and can form tumor-like nodules that clinically simulate malignancy in various organs. Clinicopathological features can be used as diagnostic markers in malakoplakia diagnosis through specific stain technology.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Oncology
Ano de publicação:
2017
Tipo de documento:
Artigo
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