Effect of bone peptide injection in patients with osteoarthritis of the activity of alkaline phosphatase / 中国生化药物杂志

ABSTRACT

Objective To analyze the effect of bone peptide injection in patients with osteoarthritis of the activity of alkaline phosphatase. Methods A total of 74 patients with osteoarthritis of the bone were selected from March 2015 to May 2017 in our hospital and were randomly divided into two groups,with 37 cases in each group.The control group was treated with glucosamine sulfate, the observation group was treated with ossotide injection.The therapeutic effect and alkaline phosphatase activity were compared between two groups. Results The total effective rate was 97.30% in the observation group, which was significantly higher than that in the control group (70.27%) (P<0.05) .The score of knee function was (79.62±5.80) in the observation group.which was significantly higher than that in the control group (71.06±5.41) (P<0.05).The alkaline phosphatase activity after the treatment of 30d and 45d (0.97±0.12), nkat/L (1.39±0.12) nkat /L was significantly higher than the control group (0.71±0.10), nkat/L, (0.88±0.10) nkat/L, the incidence rate of adverse reaction(5.41 %) was significantly lower than the control group (24.32 %) (P<0.05). Conclusion Bone peptide injection has significant therapeutic effect on bone and joint osteoarthritis, can effectively improve the knee joint function of the patients, improve the patients with alkaline phosphatase activity, and high safety, is worthy of promotion.