Influence of tanshinone injection combined diltiazem on vascular endothelial function in patients with hypertension / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of tanshinone injection combined diltiazem on vascular endothelial function in patients with hypertension.Methods:A total of 136 inpatients with essential hypertension were selected from our hospital. According to random number table,they were randomly and equally divided into diltiazem group and combined treatment group (received tanshinone injection combined diltiazem).Blood pressure,endothelium dependent dilation (EDD)were compared between two groups before,two weeks and one month after treatment.Results:Compared with before treatment [combined treatmant group: (168.25 ± 12.54)/ (112.47 ±6.28)mmHg;diltiazem group: (168.37 ± 1174.16)/(112.49±7.13)mmHg],there was significant reduction in blood pressure in two groups on two weeks and one month af-ter treatment;compared with diltiazem group on two weeks and one month after treatment,there was significant reduction in blood pressure [two weeks:(151.36±6.16)/ (109.17±4.76)mmHg vs.(142.37±2.43)/ (100.43±5.19)mm-Hg,one month:(142.34±6.28)/ (94.16±6.28)mmHg vs.(126.71 ±8.17)/ (87.49±5.37)mmHg]in combined treatment group,P <0.01 all.Compared with before treatment [Combined treatmant group:(4.78±2.30)%;diltiazem group:(4.74±2.28)%],there was significant rise in EDD in two groups on two weeks and one month after treatment;compared with diltiazem group on one month after treatment,there was significant rise in EDD [(6.69 ±4.60)% vs. (8.43±4.73)%]in combined treatment group,P <0.05 or <0.01. Conclusion:Diltiazem combined tanshinone injection can help to improve vascular endothelial function in patients with hypertension.