A Case of Extramammary Paget's Disease Treated with 5% Imiquimod Cream / 대한피부과학회지

ABSTRACT

Extramammary Paget's disease (EMPD) is an uncommon malignancy involving the epidermis, which sometimes extends into the dermis. Current treatments for EMPD are surgical excision, Mohs micrographic surgery, or laser ablation. We report a case of a 50-year-old man who presented with EMPD. The patient refused to undergo surgery and, as an alternative, he applied 5% imiquimod cream, an immune response modifier, on a daily basis for 8 months. During the initial weeks of therapy, he experienced moderate erythema and flu-like symptoms. However, imiquimod treatment resulted in clinical and histological eradication of EMPD after 8 months with no recurrence during the 18 month follow-up period.