The study on the association between neuronal nicotinic acetylcholine receptor subunit genes and type 2 diabetes in Chinese Han schizophrenics / 中国神经精神疾病杂志

ABSTRACT

Objective To explore the relationships between neuronal nicotinic acetylcholine receptor subunit gene polymorphisms and type 2 diabetes in Chinese han schizophrenics.Methods Five single nucleotide polymorphisms(SNPs )of CHRNA3 (rs1317286),CHRNA4 (rs1044396),CHRNA 7 (rs6494212) and CHRNA5 (rs16969968,rs684513) gene were analyzed in a sample of 346 schizophrenics with type 2 diabetes and 360 schizophrenics without type 2 diabetes.The five markers were genotyped by the TaqMan fluorogenic detection method with the ABI7900.Results There were no significant differences in alleles and genotypes distribution of the five genes between two groups (P＞0.05).For the CHRNA 7(rs6494212),there were significant difference in genotypes (P=0.039) and alleles distribution (P＜0.021) between two groups in male patients.The haplotypes constructed by markers of CHRNA5 were not associated with the 2 diabetes in Chinese Han male schizophrenics.The interaction analysis revealed a significant association between models made up by rs1317286,rs1044396,rs6494212,rs684513and 2 diabetes in Chinese Han male schizophrenics (P=0.002).Conclusion The CHRNA7(rs6494212) gene may be one of common susceptible genes for 2 diabetes in Chinese Han male schizophrenics.There is a significant association between models made up by rs131726rs1044396,rs6494212,rs684513 and schizophrenics with type 2 diabetes.