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Primary anti-D Immunization by DEL Red Blood Cells / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine ; : 361-365, 2009.
Artigo em Inglês | WPRIM | ID: wpr-66133
ABSTRACT
Extremely weak D variants called DEL are serologically detectable only by adsorption-elution techniques. A nucleotide change of exon 9 in RHD gene, RHD (K409K, 1227G>A) allelic variant is present in almost all the DEL individuals of East Asians. No DEL phenotype has yet been shown to induce a primary alloanti-D immunization in East Asia. A 68-yr-old D-negative Korean man was negative for anti-D at admission, and he developed alloanti-D after transfusion of red blood cells (RBC) from 4 apparently D-negative donors. Four donors who typed D-negative by routine serologic test were analyzed by real-time PCR for RHD gene and RHD (K409K). One donor was found to have RHD (K409K). This is the first case in which DEL RBCs with RHD (K409K) induced a primary alloanti-D immunization in Asian population. Because the DEL phenotype can induce an anti-D immunization in D-negative recipients, further discussion is needed whether RhD negative donors should be screened by molecular method and what an efficient genotyping method is for detecting the RHD gene carriers in Korea.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenótipo / Sistema do Grupo Sanguíneo Rh-Hr / Doadores de Sangue / Transfusão de Sangue / Tipagem e Reações Cruzadas Sanguíneas / Reação em Cadeia da Polimerase / Éxons / Isoanticorpos Limite: Idoso / Humanos / Masculino Idioma: Inglês Revista: The Korean Journal of Laboratory Medicine Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenótipo / Sistema do Grupo Sanguíneo Rh-Hr / Doadores de Sangue / Transfusão de Sangue / Tipagem e Reações Cruzadas Sanguíneas / Reação em Cadeia da Polimerase / Éxons / Isoanticorpos Limite: Idoso / Humanos / Masculino Idioma: Inglês Revista: The Korean Journal of Laboratory Medicine Ano de publicação: 2009 Tipo de documento: Artigo