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Successful pharmacotherapy for asthma exacerbation in an asthmatic patient with long QT syndrome / 대한내과학회지
Korean Journal of Medicine ; : S249-S253, 2009.
Artigo em Coreano | WPRIM | ID: wpr-66148
ABSTRACT
beta -Blockers can cause bronchospasm in asthma. beta 2-agonists prolong the QT interval and alter the clinical course of long QT syndrome (LQTS). We report a case of asthma exacerbation treated cautiously with beta 2-agonists in a patient with LQTS, while LQTS was controlled with low-dose beta 1-antagonists. A 31-year-old woman with LQTS visited the emergency room for asthma exacerbation. FEV1 was 0.5 L (18%) and QTc interval was 520 ms. Low doses of salbutamol or salmeterol were used and gradually increased, while monitoring the QT interval. Simultaneously, a low dose of atenolol was maintained. FEV1 was increased to 2.2 L (83%) without further QT prolongation or cardiac events. The case suggests that lower doses of beta 1-antagonists can be tried for cardiac diseases, even in the presence of asthma exacerbations. beta 2-Agonists may be initiated at lower doses and, if tolerated, the dose can be increased in asthmatic patients with a risk for QT prolongation.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Asma / Atenolol / Síndrome do QT Longo / Espasmo Brônquico / Agonistas Adrenérgicos beta / Antagonistas Adrenérgicos beta / Albuterol / Emergências / Xinafoato de Salmeterol / Cardiopatias Limite: Adulto / Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Asma / Atenolol / Síndrome do QT Longo / Espasmo Brônquico / Agonistas Adrenérgicos beta / Antagonistas Adrenérgicos beta / Albuterol / Emergências / Xinafoato de Salmeterol / Cardiopatias Limite: Adulto / Feminino / Humanos Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 2009 Tipo de documento: Artigo