Clinical Observation of Yishen Huashi Granules Combined with Losartan Potassium Tablets in the Treat-ment of Chronic Glomerulonephritis / 中国药房

ABSTRACT

OBJECTIVE:To observe the effects of Yishen huashi granules combined with Losartan potassium tablets on renal function indexes and inflammatory factors of patients with chronic glomerulonephritis. METHODS:A total of 107 patients with chronic glomerulonephritis in our hospital during Jan. 2015-Aug. 2016 were divided into observation group(53 cases)and control group(54 cases)according to therapy plan. Besides basic therapy,control group was given Losartan potassium tablets 50 mg,po, qd;observation group was additionally given Yishen huashi granules 10 g,po,tid,on the basis of control group. Both groups were treated for consecutive 2 mouths. Clinical efficacies,renal function indexes(Scr,BUN,24 h urine protein quantification,urine red blood cell)and inflammatory factors(IL-13,CRP,TNF-α)levels were all observed in 2 groups,and the occurrence of ADR was recorded. RESULTS:Clinical total response rate of observation group(86.79%)was significantly higher than that of control group(66.67%),with statistical significance(P<0.05). Before treatment,there was no statistical significance in renal function in-dexes or inflammatory factors levels between 2 groups(P>0.05).After treatment,renal function indexes and inflammatory factors levels of 2 groups were significantly decreased;and observation group was significantly lower than control group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:Yishen huashi granules com-bined with Losartan potassium tablets in the treatment of chronic glomerulonephritis can improve renal function and reduce inflam-mation factor level with good safety.