Research progress on long noncoding RNA in urothelial bladder carcinoma / 中国肿瘤临床

ABSTRACT

Long noncoding RNAs (lncRNAs) are endogenous RNA molecules with length of more than 200 bp, without specific open reading frame, and almost without protein coding function. LncRNA can regulate gene expression at transcriptional, post-transcription-al, and epigenetic levels. Thus, this molecule affects diverse biological processes. LncRNA may function as an oncogene or anti-onco-gene in urothelial bladder carcinoma. Moreover, this molecule is closely related not only to the diagnosis, treatment, and prognosis of urothelial bladder carcinoma but also to the proliferation, migration, and invasion of tumor cells. Progress on the study of lncRNA in bladder cancer and the relationship between lncRNA and occurrence and development of bladder cancer was discussed. A new direc-tion for the exploration of molecular markers and targeted therapies for bladder cancer is provided.