Expression and clinical significance of Survivin and human epidermal growth factor receptor-2 in breast cancer tissue / 中国综合临床

ABSTRACT

Objective To investigate the expression and clinical significance of Survivin and human epidermal growth factor receptor-2 in breast cancer tissue.Methods Eighty-seven cases of patients with breast cancer treated in Jizhong Energy Fengfeng Group Hospital from October 2010 to December 2016 were analyzed.All of them were diagnosed as invasive ductal carcinoma of breast by pathological diagnosis.Normal tissue adjacent to the tumor(more than 5 cm)was collected as the control group.The expression of Survivin and human epidermal growth factor receptor -2 in breast lesions was detected by immunohistochemical SP method.The correlation between Survivin and human epidermal growth factor receptor -2 was analyzed through the comparison of their expression of different clinical pathological features in breast cancer patients.Results The positive rate of Survivin in the breast cancer group was 69.0%(60/87),and 4.6%(4/87)in the control group.The difference between the two groups was statistically significant(P=0.000).The positive rate of human epidermal growth factor receptor -2 in cancer tissues was 46%(40/87)in the breast cancer group,and 0(0/87)in the control group.The difference between the two groups was statistically significant(P=0.000).The expression of survivin was not related to the age,tumor diameter and histological grade of breast cancer patients, but was related to lymph node metastasis(P<0.05).The expression of human epidermal growth factor receptor-2 was not related to the age,tumor diameter of breast cancer patients,but was related to tissue grading and lymph node metastasis(P<0.05).Spearman correlation analysis showed that human epidermal growth factor receptor-2 was positively correlated with survivin(r=0.412,P<0.05).Conclusion Survivin and human epidermal growth factor receptor-2 are associated with the development and progression of breast cancer,both of which play a coordinating role in the development and progression of breast cancer.They play an important role in the process of tumor invasion and metastasis.